Total lesion glycolysis (TLG): It was automatically calculated by multiplying the selected PET volume (MTV) on the investigated lesions as mentioned above by the SUVmean within that volume [TLG=MTV X SUV mean]. FDG is widely used in PET scanning. Findings: Deauville 5. Positron emission tomography (PET) scan: The PET scan will light up the nodule if it is rapidly growing or active. Yes, I've had a 5 and currently still alive. In our schema, a complete metabolic response (CMR) is defined as a return of FDG uptake in previously documented lesions to a level equivalent to, or less than, residual radioactivity in normal tissues within the organ in question. 2015 Jul;170(2):185-91. doi: 10.1111/bjh.13420. Check for errors and try again. An improved image quality may affect visual scoring systems, including the Deauville score (DS), which is used for clinical assessment of patients with lymphoma. (c) Late interim therapeutic response after 6 additional chemotherapy cycles, showed complete metabolic resolution of the previously noted lymph nodal and bone marrow disease (apart from equivocal iliac bone marrow FDG uptake). Objective To investigate the prognostic value of SUV and Deauville 5-point scoring (5-PS) in patients with DLBCL. In this study, 5p-DS and rDS were obtained considering the same reference organ (liver parenchyma). Articles. Prognosis for Stage IV Hodgkin's Lymphoma & Patient Expectations. Qualitative data were expressed as frequency and percentage. Non-Hodgkin lymphoma (NHD) was found in 55 patients (61.8%), while Hodgkin lymphoma was found in the remaining 34 patients (38.2%). 4. 1 and 2). The Lugano Classification uses the same scale as the Deauville score but refers to it as a 5 point score (5PS). Concordance between four European centres of PET reporting criteria designed for use in multicentre trials in Hodgkin lymphoma. Normal lymphatic tissue may display low to moderate FDG uptake in the head and neck region. {"url":"/signup-modal-props.json?lang=us"}, Pfleger R, Bell D, Knipe H, et al. We, therefore, suggest that the discrepancy between the recommended rPET value and 1.00 may be related to the rPET MU that should be taken into account [8, 9]. Patients were treated according to the hospital protocol in respect of their risk groups as follows: For Hodgkins lymphoma, low-risk group patients were treated with four cycles of ABVD+IFRTH, intermediate-risk group patients were treated with six cycles ofIFRTH, and high-risk group patients were treated with eight cycles of ABVD. Interestingly, with all 3 . Score 3 should be interpreted according to the clinical context but in many Hodgkin Lymphoma patients indicates a good prognosis with standard treatment. GIT and BM were the most frequently involved extra-nodal sites. In previous studies,9 12 5-DS of scores of 13 were defined as negative scans, and scores of 45 were considered to be a positive result. Please enable it to take advantage of the complete set of features! What are the differences between a male and a hermaphrodite C. elegans? From these segmentations, 107 features were . Patients received an intravenous injection of 5.55 megabecquerel (MBq)/kg (0.15 milli-Curie/kg) body weight dose of 18F-FDG (minimum dose, 74MBq (2mCi). (c) Late interim therapeutic response after 6 additional chemotherapy cycles, showed complete metabolic resolution of the previously noted lymph nodal and bone marrow disease (apart from equivocal iliac bone marrow FDG uptake). Interim PET results have been interpreted using two different methods: Using Deauville score, which depends on the visual comparison of activity between residual lesion/s and reference activities (liver and mediastinum) (Table 1), we divided our studied patients into two groups (positive and negative early response PET). If desired, an "X" designation may be used in conjunction with the 5 . Interim PET was interpreted using both visual (5p-DS) and the semiquantitative method (rDS). Articles are a collaborative effort to provide a single canonical page on all topics relevant to the practice of radiology. Qualitative parameters Any focal uptake, higher than mediastinal or hepatic reference, was interpreted as abnormal FDG uptake. In the multivariate analysis, DS was still a significant factor for recurrence-free survival [hazard ratio (HR), 3.840 and confidence interval (CI), 1.068-13.806; P = 0.039] and overall survival rates (HR 4.453 and CI 1.274-15.562; P = 0.019). The rDS approach uses the strictly quantitative target-to-liver SUVmax ratio, without any connection to a visual analysis. A PET scan is an effective way to help identify a variety of conditions, including cancer, heart disease and brain disorders. Duration of response is the time from response (R) to progression/death (P/D). In a comparison between Deauville and ratio Deauville score in interpretation of interim PET, the results were matched in all cases except in 2 patients who were positive in DS and negative in ratio Deauville score as showed in Figs. The selection process included patients who fulfilled the criteria given below: Children less than 18years, with pathologically proved FDG avid either Hodgkin or non-Hodgkin lymphoma; patients with lymphomatous extra-nodal involvement either primary or secondary; and whole-body FDG PET/CT study done at initial staging and after two cycles of CTH. Low grade lymphomas can be localized in the initial stages, or in severe cases it can spread to different sites. Clinical implications of positron emission tomography-negative residual computed tomography masses after chemotherapy for diffuse large B-cell lymphoma. Your prognosis is a best guess at your chances of recovering from lymphoma after treatment. Google Scholar, Friedberg J, Chengazi V (2003) PET scans in the staging of lymphoma: current status. bouquinistes restaurant paris; private client direct jp morgan; show-off crossword clue 6 letters; thermage near illinois; 2012 kia sportage camshaft position sensor location https://doi.org/10.1186/s43055-022-00899-6, DOI: https://doi.org/10.1186/s43055-022-00899-6. 3) showed a sensitivity of 91.7%, while and the second value showed a sensitivity of 83.3%. After a mean follow-up period of 24months (range 640months), 7 out of 65 children in the early response (interim) negative group, assessed by using DS, showed disease relapse, while in the DS early response positive group, 9/24 patients showed bad response (4 of them were refractory to treatment and the other 5 patients relapsed after the end of therapy) with a significant statistical difference regarding disease relapse between interim negative and positive groups (P value=0.002) as illustrated in Fig. The World Health Organization (WHO) classification of non- Hodgkins lymphoma (NHL) recognizes more than 30 different subtypes of NHL. Moreover, the difference in 5-year TTP prognosis between Deauville score 4 and Deauville score 5, was 33% and 87%, respectively, P = 0.0002). Stuff like that. VOI is identified and drawn, for each lesion either nodal or extra-nodal lesion automatically for generating 3D iso-count contours using a fixed threshold of 40% of the SUVmax (V40%). . However, this is not always true and can cause unnecessary alarm and concern. In most situations where standard treatment will be given, a Deauville score (DS) of 3 represents a complete metabolic response (CMR). In a trial to compare the prognostic significance of visual and ratio Deauville score, we calculated rDS ratios in all patients and calculated the best cutoff value that may predict prognosis. For an rPET/rDS outcome of 1, that is, when the borderline equality target "SUVmax = liver SUVmax" is found in clinical practice, the corresponding metabolic uncertainty (MU) provides the upper and lower limits of the confidence interval around the outcome of 1 (CI; usually given with 95% reliability) where the "true rPET" value may range. F-fluorodeoxyglucose (FDG) PET/CT is a pivotal imaging modality for cancer imaging, assisting diagnosis, staging of patients with newly diagnosed malignancy, restaging following therapy and surveillance. government site. Hodgkin's lymphoma is a treatable cancer. The agreement between the visual and quantitative Deauville scales was good. Vitolo U, et al. After a median follow-up time of 37.2 months, the recurrence-free survival rate (86.6% vs. 66.8%, P = 0.041) and overall survival rate (86.9% vs. 62.2%, P = 0.009) at 5 years were significantly different between the DS 1-3 and DS 4-5 arms. PMC Unable to process the form. Stages I, II, III, and IV were included in our study with the following numbers (8, 19, 4, and 56 patients, respectively). A tumor marker (if applicable) may fall within the normal range. Overall survival was not used as an endpoint due to the small number of deaths. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Shown are the criteria for interpretation of interim FDG-PET/CT. [18F] fluorodeoxyglucose positron emission tomography predicts survival after chemoimmunotherapy for primary mediastinal large B-cell lymphoma: Results of the international extranodal lymphoma study group IELSG-26 Study. Annunziata et al. Most patients with Hodgkin lymphoma live long and healthy lives following successful treatment. The predictive role of interim positron emission tomography for Hodgkin lymphoma treatment outcome is confirmed using the interpretation criteria of the Deauville five-point scale. All authors read and approved the final manuscript. For non-Hodgkins lymphoma, treatment depends on histological subtype as well as risk stratification. Interim PET-CT in the management of diffuse large B-cell lymphoma. Although the interpretation of interim PET (after two cycles of chemotherapy) using the qualitative visual method of 5-point Deauville score has been widely accepted, semiquantitative methods of interpretation were evaluated by many studies and showed a better prediction of prognosis. A Biblioteca Virtual em Sade uma colecao de fontes de informacao cientfica e tcnica em sade organizada e armazenada em formato eletrnico nos pases da Regio Latino-Americana e do Caribe, acessveis de forma universal na Internet de modo compatvel com as bases internacionais. 2019 Oct 23;60(5):677-684. doi: 10.1093/jrr/rrz043. Some types of lymphoma are more common in children and young people than in adults, and they can be treated differently. (2013) Leukemia & lymphoma. The .gov means its official. OM performed the statistical analysis of data. This camera integrates a PET scanner with a dual-section helical CT scanner and allows the acquisition of co-registered CT and PET images in one session. PDF | Background Pediatric lymphoma is a common hematological neoplasm, representing the third most frequent childhood malignancy.. | Find, read and cite all the research you need on ResearchGate To the right: Interim PET-CT study shows complete disappearance of DV7 lesion with a still residual lesion at sternum with SUVmax~2.2. Of the 571 patients who completed 3 cycles of ABVD, 145 had a positive PET scores of 3, 4 or 5 and then these patients received a fourth cycle of ABVD plus radiation. Progression-free survival curves for rDS above and below the cutoff value. Haematologica. (NB: Some patients had lesions overlapped in more than one extra-nodal site. The follow-up period for all patients ranged between 6 and 40 months with a mean of 24 months. 2. Score 3 should be interpreted according to the clinical context but in many Hodgkin Lymphoma patients indicates a good prognosis with standard treatment. Regarding the univariate analysis of our results, semiquantitative parameters of the highest FDG-avid lesions in initial PET study were not correlated with survival. . Vulcan Productions produced documentary films, television programming and virtual reality experiences that drove awareness around environmental and social issues. A 4 or 5 Deauville score assessed by (18)F-FDG-PET CT early post-allotransplant is highly predictive of relapse in lymphoma patients . SUV value is defined as the tissue concentration of tracer as measured by a PET scanner divided by the activity injected divided usually by body weight [1]. J. Nucl. J. Clin. Moreover, we found that the progression-free survival in patients with rDS more than 1.25 (our selected cutoff) was lower than that of positive DS (score 4 and 5). Progression-free survival in prognostic subgroups derived from the quantitative Deauville scale (top) and the SUV max scale (bottom) (Kaplan-Meier analysis). To the left: Initial study shows metabolically active FDG-avid infiltrates involving both kidneys, bone marrow, and bone. PET works by using a scanning device (a machine with a large hole at its center) to detect photons (subatomic particles) emitted by a radionuclide in the organ or tissue being examined. Deauville. https://doi.org/10.1007/s00259-014-2715-9, Van de Wiele C, Kruse V, Smeets P, Sathekge M, Maes A (2013) Predictive and prognostic value of metabolic tumour volume and total lesion glycolysis in solid tumours. This approach seemed to make it easier to screen and identify high-risk patients, and thus, it may predict . All statistical calculations were done using computer program IBM SPSS (Statistical Package for the Social Science; IBM Corp, Armonk, NY, USA) release 22 for Microsoft Windows. PET scans were analyzed using Deauville score (DS) and change in maximum standardized uptake value (SUVmax). CAS stable disease (SD), also called no metabolic response: a Deauville score of 4 or 5 without significant change in FDG uptake from baseline. The side effects of chemotherapy occur as a result of this damage. Of the 10 patients with an end-of-therapy Deauville score of 4 or 5, four had a diagnosis of relapse or refractory disease based on end-ofchemotherapy imaging alone. Accurate interpretation of early response evaluation PET (interim PET) is crucial for achieving the best management strategy for lymphoma patients; however, it is still a subject of ongoing debate. The site is secure. Lymphoma most often spreads to the liver, bone marrow, or lungs. Below are the 5-year relative survival rates for two common types of NHL - diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) - based on people . As previously mentioned, the signs and symptoms of MCL are dependent on the extent of the region of the body that is affected. All images were qualitatively and quantitatively interpreted. 8600 Rockville Pike Privacy Again, at the end . Before What is a good Deauville score? . Would you like email updates of new search results? Other tracers are also used in PET to image the tissue concentration. We performed a It takes advantage of two reference points of the individual patient,which have demonstrated relatively constant uptake on serial imaging. The International Nuclear Information System is operated by the IAEA in collaboration with over 150 members. Your doctor can use this information to help diagnose, monitor or treat your condition. "Pretransplant total lesion glycolysis value . By using this website, you agree to our Br J Haematol. Methods Thirty-nine patients (20 males,19 females;median 58 (23-85) years) with pathologically confirmed DLBCL were retrospectively analyzed from January 2009 to April 2015. Generally, for people with non-Hodgkin lymphoma in England: around 80 out of every 100 people (around 80%) survive their cancer for 1 year or more after they are diagnosed. Progression-free survival (PFS) was used as our study end point in relation to ratio Deauville score results (rDS). Involved extra-nodal sites are illustrated in Table 3. Scores of 1 and 2 are considered to be negative and 4 and 5 are considered to be positive. HM and MH revised the results and discussion. Deauville score was developed at Guy's and Saint Thomas Hospital in London after an . Progression-free survival (PFS) was used as our study end point in relation to ratio Deauville score results (rDS). Moskowitz CH. A Deauville score of 4 indicates that the lesion FDG uptake is moderately greater than the liver activity, whereas a Deauville score of 5 indicates that the lesion FDG up-take is markedly greater than the liver up-take, typically 2-3 times more intense (Figs. It is also known as the dose uptake ratio (DUR). The interpretation of early response evaluation PET (interim PET done after two cycles of CTH) is a subject of ongoing debate. 4. Multivariate analysis was difficult to be done because of the limited number of significantly correlated factors in the univariate analysis. Lesion-to-Liver SUVmax Ratio to Improve the Prognostic Value of the End of Treatment PET/CT in Diffuse Large B-Cell Lymphoma. Recently, a ratio between semiquantitative parameters (e.g., target lesion and liver SUV) has been proposed for interim FDG-PET/CT interpretation as it allows conversion of the visual qualitative scale to a continuous semiquantitative scale and permits evaluation of interim FDG-PET/CT through a well-determined semiquantitative-based cut-point [5]. I am currently continuing at SunAgri as an R&D engineer. Reference article, Radiopaedia.org (Accessed on 02 Mar 2023) https://doi.org/10.53347/rID-32555, diffuse large B cellular lymphoma (DLBCL), WHO classification of neoplastic diseases of lymphoid tissues. Barrington SF, Qian W, Somer EJ et-al. The brighter the nodule appears on the PET scan, the more likely that it is cancer. Partial response the cancer has shrunk by a percentage but disease remains. We also divided interim positive patients according to the number of residual diseased sites in interim PET study into three groups (single residual, two sites, or multiple sites3) and studied the effect of number of these residual sites on prognosis. Results: When Deauville 5-point scale (5-DS) scores of 4-5 were classified as a positive scan (denoted by DS [score 4]), there was no significant difference in progression-free survival (PFS) between I-PET positive and negative patients (P=0.151). Chemotherapy kills cells that multiply quickly, such as lymphoma cells. Sedation was used in most of the patients. This study showed and validated that Deauville score of 4-5 of PET-CT imaging taken after full-course of R-CHOP chemotherapy with or without RT could predict recurrence-free survival and overall survival in DLBCL patients. Abdominal US revealed bilateral kidney masses that were pathologically proved to be non-Hodgkins lymphoblastic lymphoma. Another sizable ROI was drawn over the normal liver where its max SUV was considered reference activity for further quantitative analysis to calculate max SUV lesion/max SUV liver ratio. . The maximum standardized uptake value (SUVmax) is widely used for measuring the uptake of FDG by malignant tissue (Gambhir 2002). (oh-ver-AWL reh-SPONTS ) The percentage of people in a study or treatment group who have a partial or complete response to the treatment within a certain period of time. Scores of 1 and 2 are considered to be negative and 4 and 5 are considered to be positive. 2022 Sep 21;11(19):5541. doi: 10.3390/jcm11195541. Scores of 1 and 2 are considered to be negative and 4 and 5 are considered to be positive. In patients whose GIT showed diffuse activity, meticulous interpretation of other findings such as the presence or absence of bowel masses, accompanied nodal or extra-nodal lesions as well as history of inflammatory bowel disease is included for final suggestion. What is the shape of C Indologenes bacteria? Our study was approved by the ethical committee of Faculty of medicine, Cairo University, and the radiation safety committee at NCI had given approval for study design. -, J Clin Oncol. HY and HF collected and interpreted the data. PubMed Although slow growing forms of NHL are currently not curable, the prognosis is still good. Our study was approved by the ethical committee of Faculty of medicine, Cairo University, and the radiation safety committee of national cancer institute had given approval for study design. A total of 512 patients with stage I-III DLBCL who received six cycles of R-CHOP with or without radiation therapy (RT) and obtained treatment responses according to PET-CT imagings after R-CHOP RT were included. Background: Total body and long-axial field-of-view (LAFOV) PET/CT represent visionary innovations in imaging enabling either improved image quality, reduction in injected activity-dose or decreased acquisition time. CT was done from the base of the skull to the mid-thighs with the arm extended above the head. Bethesda, MD 20894, Web Policies PET works by using a scanning device (a machine with a large hole at its center) to detect photons (subatomic particles) emitted by a radionuclide in the organ or tissue being examined. [1] The term aggressive NHL refers to those subtypes that grow rapidly (proliferation index > 40%) and would often be fatal within months without appropriate therapy. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. The tonsils, Waldeyers ring and spleen are considered nodal tissue for staging. Regarding our study, we found that initial parameters predictive of early response (bone marrow infiltration and number of involved extra-nodal sites at initial presentation) were identical to those predicting survival with the exception of B symptoms that can predict prognosis not early response. Positron emission tomography (PET) scan: The PET scan will light up the nodule if it is rapidly growing or active. Patients with a positive 5p-DS had a 3-year PFS of 67.4%, while patients with rDS>1.25 had a 3-year PFS of 60%. Univariate survival analysis was performed using the Kaplan-Meier . [11] studied 119 adult patients with newly diagnosed DLBCL and found that a higher interim2 cutoff value of 1.6 achieves the highest specificity and makes more accurate reproducibility and outcome prediction. Med. 2013;54 (5): 683-90. Terms and Conditions, The standard uptake value (SUV), also known as standardized uptake value, is a simple way of determining activity in PET imaging, most commonly used in fluorodeoxyglucose (FDG) imaging. Version A B Submitted Date Changes; 1: October 13, 2017: None (earliest Version on record) 2: November 22, 2017: Recruitment Status, Study Status and Contacts/Locations: 3: November 30, 2017: Study Status, Contacts/Locations and Study Identification Deauville score versus ratio Deauville score in the interpretation of interim 18F-FDG PET-CT and in prediction of outcome in children with FDG-avid extra-nodal lymphomas, https://doi.org/10.1186/s43055-022-00899-6, Egyptian Journal of Radiology and Nuclear Medicine, https://doi.org/10.1007/s00259-014-2973-6, https://doi.org/10.1007/s00259-014-2715-9, https://doi.org/10.1007/s00259-012-2280-z, https://doi.org/10.1080/10428190903040048, https://doi.org/10.1371/journal.pone.0211649, https://doi.org/10.21147/j.issn.1000-9604.2017.01.07, http://creativecommons.org/licenses/by/4.0/. This finding suggests that . 2023 BioMed Central Ltd unless otherwise stated. The DS interim negative group included 65 patients, while the positive group included 24 patients. Manage cookies/Do not sell my data we use in the preference centre. The associations between PET/CT results and progression-free survival (PFS) and overall survival (OS) were assessed using Cox regression analysis. Patients with negative 5p-DS and patients with rDS<1.25 had a similar 3-year PFS (87%). Epub 2020 Jul 4. In patients with a Deauville score of 4, the recommended treatment options include 2 additional cycles of ABVD (total of 4) or 2 cycles of escalated BEACOPP followed by restaging with PET. ROC curve analysis of our selected cutoff value. Standardized uptake value (SUV): It was recorded for each lesion in each patient after manual application of the volumetric regions of interest on the trans-axial attenuation-corrected PET slices, around the areas demonstrating the greatest accumulation of 18F-FDG and away from any nearby overlapping activity. It is a fluorine isotope with a half life of approximately 110 minutes. In our study, patients with iPET Deauville 1-3, 4 and 5 not only had different survival time, but also had different eCRR to R-CHOP regimen. FDG-PET/CT after two cycles of R-CHOP in DLBCL predicts complete remission but has limited value in identifying patients with poor outcome - final result of a UK National Cancer Research Institute prospective study. From the 89 children with proved extra-nodal lymphoma, 66 (74.2%) were males and 23 (25.8%) were females. Chi-square test (Fishers exact test) was used to examine the relation between qualitative variables. Disclaimer. Moreover, regarding our results, patients with rPET more than 1.25 had a worse prognosis than patients with positive 5p-DS (PFS at 3years of 60% and 67.4%, respectively). That score is just the likelihood of lymphoma, not anything related to how bad. Oncol. A total of 512 patients with stage I . CI, confidence interval Which type of chromosome region is identified by C-banding technique? Score 3 should be interpreted according to the clinical context but in many Hodgkin's Lymphoma patients indicates a good prognosis with standard treatment. Regarding our study, both visual and semiquantitative assessments of interim PET were significantly correlated with prognosis. 12 month progression-free survival (PFS) [ Time Frame: 1 year post-transplant ] . The Deauville score relates tumor uptake values to those of the liver and the mediastinum. Normal lymphatic tissue may display low to moderate FDG uptake in the head and neck region. [9], on 181 patients with DLBCL, ROC analysis revealed the optimal cutoff value to be 1.4-fold of SUVmax-liver on iPET4 which is higher than our cutoff point that can be explained by different timing of interim PET (iPET4 not iPET2) that may be affected by posttherapy inflammatory changes, while Fan et al. Elhamady, H.Y., Mostafa, H.M., Elsayed, H.F. et al. Recommendations for Initial Evaluation, Staging, and Response Assessment of Hodgkin and Non-Hodgkin Lymphoma: The Lugano Classification. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Corresponding Deauville criteria score 4. Mol. 5, 6, and 7. Advertisement. At that point, their therapy was de-escalated to AVD [Adriamycin vinblastine dacarbazine] and they completed a total of 6 cycles of therapy. The authors declare that they have no competing interests. For patients using the Deauville score PET-CT scan (n = 103), the percentage of PET-negative cases (Deauville score 1-3) was 91%. 2016 Sep;43(10):1837-48 PubMed Google Scholar, Fan Y-G, Zhang Y, Yang Z, Ying Z, Zhou N, Liu C, Song Y-Q, Zhu J, Wang X-J (2017) Evaluating early interim fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography with the SUVmax-liver-based interpretation for predicting the outcome in diffuse large B-cell lymphoma. HY was the major contributor in writing the manuscript. Theres a perception among patients that anything with uptake is abnormal. Deauville is a posh seaside resort in Normandy, France. Results: A totally 145 patients with a mean age of 71.469.26, were evaluated. Hadeer Yousef Elhamady. Scores of 1 and 2 are considered to be negative and 4 and 5 are considered to be positive. J. Clin. FDG uptake refers to the amount of radiotracer uptake. The 5-point scoring system (5p Deauville Score) has been widely accepted as a rapid qualitative method to evaluate interim FDG-PET/CT through visual comparison of uptake between residual lesion and reference regions (mediastinum and liver). Lung cancer is the leading cause of cancer-related mortality globally, and lung adenocarcinoma is the most frequent histologic subtype [ 1 ]. , Waldeyers ring and spleen are considered nodal tissue for staging designation may used. Both visual ( 5p-DS ) and overall survival was not used as our study end point in to. 5-Ps ) in patients with DLBCL lymphoblastic lymphoma of our results, semiquantitative parameters of the to! Cause unnecessary alarm and concern is affected with the arm extended above the head and region... At the end the signs and symptoms of MCL are dependent on the PET scan is an effective to! Tracers are also used in conjunction with the arm extended above the and... 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Of Health and Human Services ( HHS ), et al lymphoma, treatment depends on histological subtype as as! Identify high-risk patients, and thus, it may predict prognosis with treatment... People than in adults, and thus, it may predict strictly quantitative target-to-liver SUVmax ratio to Improve prognostic... We performed a it takes advantage of two reference points of the body that is.... Of the region of the liver and the semiquantitative method ( rDS ) ( 2003 ) PET scans the! Initial evaluation, staging, and they can be treated differently a sensitivity of 91.7,. The end of treatment PET/CT in diffuse large B-cell lymphoma performed a it takes advantage the! Diffuse large B-cell lymphoma patients indicates a good prognosis with standard treatment in... After an:677-684. doi: 10.1093/jrr/rrz043 individual Patient, which have demonstrated relatively constant on. Barrington SF, Qian W, Somer EJ et-al significantly correlated factors in the management of diffuse large lymphoma... 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