Now, in an article published in the prestigious journal Molecular Cell, the lab of Dr. Sebastian Kadener at the Hebrew University of Jerusalem, in collaboration with the lab of Prof.. In particular, we are using BioID to systematically characterize the secretome from various tissues to identify novel interorgan communication factors. Our laboratory is interested for understanding how molecular processes in the brain determine behavior with special emphasis on RNA metabolism. Jens is co-mentored by Dr. David Jones at the DKFZ. Murugan et al. Rosi is accepted to attend the Autumn Workshop in Structural Proteomics in Nurmes, Finland and was chosen to receive a COST scholarship. Additionally, many of the mechanisms by which growth factortriggered signaling events intersect with cell metabolism, which is regulated by nutrients, hormones and stress, remain to be identified. Weiss R., Bartok O., Mezan S., Malka Y and Kadener S. Synergistic Interactions between the Molecular and Neuronal Circadian Networks Drive Behavioral Circadian Rhythms in. We have several efforts underway to produce new binary expression system reagents by CRISPR-mediated knock-in, including split-GAL4, LexA, and QF. For example, we identified a number of ion channels that either directly or indirectly regulate stem cell proliferation. Riley is currently working to understand genetic and epigenetic mechanisms of resistance in brain tumors, focusing on resistance to BET-bromodomain inhibitors and vulnerabilities induced by loss of mismatch repair proteins. CRISPR-generated mutant cell lines, in combination with RNAi, provide a robust platform for combinatorial screening. ONLINE COVER Cartilaginous core of an African clawed frog's regenerated hindlimb after exposure to a multidrug treatment. Recent reports revealed that circRNAs are expressed in developmental- and tissue-specific manners and are highly enriched in the nervous system, particularly in synapses. Mezan S., Ashwal-Fluss R., Shenhav R., Garber M. and Kadener S. Genome-wide assessment of post-transcriptional regulation in the fly brain. Mouse-olfactory bulb, brain stem, and thalamus-Mock. An early ancestor in the evolution of splicing: a. Nogues G., Kadener S., Cramer P., de la Mata M., Fededa J.P., Blaustein M., Srebrow A. and Kornblihtt A.R. Simchovitz A, Hanan M, Niederhoffer N, Madrer N, Yayon N, Bennett ER, Greenberg DS, Kadener S, Soreq H. Thermosensitive alternative splicing senses and mediates temperature adaptation in, Reconfiguration of a Multi-oscillator Network by Light in the. The Kadener laboratory studies how molecular processes in the brain determines behavior with a special emphasis on RNA metabolism. Two of these RNAs act as miRNA sponges, but no function is known for the thousands of other circRNAs found in species across the animal kingdom. Fun fact: Anna is a gardening nerd on hold, as she does not have a garden in Boston. We are particularly interested on the role of circular RNAs (circRNAs) at the molecular and neural levels as well as the mechanisms underlying circadian clocks. Lacadie S.A., Tardiff D.F., Kadener S. and Rosbash M. In vivo commitment to yeast cotranscriptional splicing is sensitive to transcription elongation mutants. A slow RNA polymerase II affects alternative splicing in vivo. Jazmin is currently investigating how circRNA levels change at synapses and whether they are modulated by neuronal activity. Selected for Faculty of 1000 (Factor 9 Exceptional). She received her BA in Molecular and Cell Biology from the University of California, Berkeley in 2019. . Jens then moved to Heidelberg in 2021 to enroll in the masters program in Cancer Biology at the German Cancer Research Center (DKFZ). I am interested in studying circular RNAs and neurological disorders. April joined the Bandopadhayay Lab in 2023 and is working on understanding the mechanisms and relationships of driver mutations commonly found in pediatric brain tumors in the hopes of developing new therapeutic strategies for these tumors. For example, we showed that circRNA biogenesis competes with canonical splicing, showing that circRNAs can function incisas RNA traps. Proximity labeling utilizes enzymes that generate reactive radicals to covalently tag neighboring proteins. Wittenbrink N, Ananthasubramaniam B, Mnch M, Koller B, Maier B, Weschke C, Bes F, de Zeeuw J, Nowozin C, Wahnschaffe A, Wisniewski S, Zaleska M, Bartok O, Ashwal-Fluss R, Lammert H, Herzel H, Hummel M, Kadener S, Kunz D, Kramer A. Levin-Klein R., Fraenkel S., Lichtenstein M., Matheson L., Bartok O., Nevo Y., Kadener S., Corcoran A., Cedar H., Bergman Y. Kadener S., Fededa J.P., Rosbash M. and Kornblihtt A.R. Mosquito cell lines exist that are able to become infected with viruses and are susceptible to mosquitocidal toxins, parasites, and drugs, but tools to allow deeper understanding of pathogen interactions with mosquito cells are lacking. I am a junior who is majoring in biochemistry. She immediately transitioned into a PhD program, still working with Dr. Swartling to continue her work on mouse models and medulloblastoma treatments. Bartok O., Kyriacou C., Levine J., Sehgal A. and Kadener S. Adaptation of molecular circadian clockwork to environmental changes: a role for alternative splicing and miRNAs. He went to college in Malaysia before moving to Philadelphia. Sher was born and raised in Rawalpindi, Pakistan and moved to the United States for his undergraduate studies. The Perrimon lab is interested in characterizing the mechanisms by which cells, tissues and organs communicate during development and in mature animals. Fededa J.P., Petrillo E., Gelfand M.S., Neverov A.D., Kadener S., Nogues G., Pelisch F., Baralle F.E., Muro A.F. leptin), neural development, and behavior are conserved, . Among the next significant questions to address are how complex phenotypes arise in the context of the whole organism and how the programs regulating these phenotypes are influenced by genetic background and environment. Additionally, many of the mechanisms by which growth factortriggered signaling events intersect with cell metabolism, which is regulated by nutrients, hormones and stress, remain to be identified. Selected for Faculty of 1000 (Factor 6 Must Read). Anna developed a fascination for cancer biology while working towards her bachelors degree at Lund University, Sweden. Nucleic Acids Research47(11): e95; 1-16 (2017). Towards the end of her time as a PhD candidate, she became exceptionally interested in the intersect between cancer metabolism and oncogenic signaling, particularly the metabolic switches that support and drive adaptive resistance to cancer therapy. In October 2021, Anna defended her PhD thesis (and Mimi had the honor of being her faculty opponent!!). Sebastian Kadener. In addition to her passion for medicine and science, Jess is also passionate about advocacy for science. Chen TC, Tallo-Parra M, Cao QM, Kadener S, Bttcher R, Prez-Vilar G, Boonchuen P, Somboonwiwat K, Dez J, Sarnow P. A lncRNA survey finds increases in neuroprotective LINC-PINT in Parkinson's disease substantia nigra. Allada R., Kadener S., Nandakumar N. and Rosbash M. A recessive mutant of, Portal D., Espinosa J.M., Lobo G.S., Kadener S., Pereira C.A., de la Mata M., Tang Z., Lin R.J., Kornblihtt A.R., Baralle F.E., Flawia M.M. The current model postulates that circadian oscillators keep time by complex transcriptional and post-transcriptional feedback loops. Melamed Z., Levy A., Ashwal R., Lev-Maor G., Mekahel N., Atias N., Gilad S., Sharan R., Levy C., Kadener S* and Ast G*. Fun fact:When not in the lab or the clinic, Jess loves yoga, sour beers, running on the Esplanade, and writing. Second, we showed that the calcium channel TrpA1 is expressed in ISCs and is required for their proliferation. Now the stage is set for the most exciting questions, which we are currently working in the lab, by combining molecular, computational and RNA biology with advances techniques in genetics and neurosciences. Chen TC, Tallo-Parra M, Cao QM, Kadener S, Bttcher R, Prez-Vilar G, Boonchuen P, Somboonwiwat K, Dez J, Sarnow P. A lncRNA survey finds increases in neuroprotective LINC-PINT in Parkinson's disease substantia nigra. We use Drosophila as a model system to characterize the mechanisms underlying communication between cells, tissues, and organs. Belacortu Y., Weiss R., Kadener S. and Paricio N. Transcriptional activity and nuclear localization of Cabut, the, Belancortu Y., Weiss R., Kadener S. and Paricio N. Expression of, Van der Linden A.M., Beverly M., Kadener S., Rodriguez J., Wasserman S., Rosbash M. and Sengupta P. Genome-Wide Analysis of Light and Temperature-Entrained Circadian Transcripts in, Fathallah-Shaykh H.M., Bona J.L. We generated a dual reporter with a destabilized fast folding GFP (dsGFP) protein and a stable RFP reporter. Informative set of videos on insect physiology and endocrinology: New paper: Cramer P., Srebrow A., Kadener S., Werbajh S., de la Mata M., Melen G., Nogues G. and Kornblihtt AR. First, we characterized a Drosophila miRNA, miR-263a, that regulates epithelial sodium channel (ENaC) activity to maintain osmotic and ISC homeostasis. PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator. de la Mata M., Alonso C.R., Kadener S., Fededa J.P., Blaustein M., Pelisch F., Cramer P., Bentley D. and Kornblihtt A.R. In the past 50 years, studies using genetically tractable model systems have led to a detailed understanding of genetic mechanisms involved in the control of developmental events, as illustrated by our knowledge of patterning and morphogenesis. Uncovering molecular and physiological functions of circRNAs: Circular RNAs (circRNAs) are highly abundant RNAs produced by circularization of specific exons. In the past 50 years, studies using genetically tractable model systems have led to a detailed understanding of genetic mechanisms involved in the control of developmental events, as illustrated by our knowledge of patterning and morphogenesis. For example, little is understood about how the simultaneous growth and differentiation of different tissues and organs are coordinated and how the development of different cell types and tissues is integrated within an organ. Rosenstiel332781-736-4915skadener@brandeis.edu, Department of Biology Volen 206MS 008 Brandeis University 415 South Street Waltham, MA 02453. cabut during early embryogenesis, dorsal closure and nervous system development. Over the years, we have added a number of screening reagents and developed bioinformatics tools to improve the platform. Zaffagni M, Kadener S. NEAT1 is overexpressed in Parkinson's disease substantia nigra and confers drug-inducible neuroprotection from oxidative stress. Precise regulation of epithelial stem cells is critical to maintain tissue integrity and prevent over-proliferation and cancer. Sebastian Kadener Principal Investigator M.Sc., The University of Buenos Aires, Buenos Aires, Argentina Ph.D., The University of Buenos Aires, Buenos Aires, Argentina skadener [at]brandeis [dot]edu Staff Sinead Nguyen Lab Manager I am interested in studying circular RNA formation. The latest Tweets from Kadener Lab (@kadenerlab): "https://t.co/VOExAyFxj9" Transcriptional activators differ in their abilities to control alternative splicing. While the former supposes a temperature-dependent balancing of reactions with opposite effects on circadian period, the . Determine the nature of circadian rhythms within organisms. Nov, 2017. Bartok O., Teesalu M., Pandey V., Hanan M., Poukkula M., Havula E., Moussaieff A., Vodala S., Nahmias Y., Kadener S.* and Hietakangas V.* Cabut-dependent repressive branch of the sugar sensing transcriptional network regulates glyceroneogenesis. Bartok O., Kyriacou C., Levine J., Sehgal A. and Kadener S. Adaptation of molecular circadian clockwork to environmental changes: a role for alternative splicing and miRNAs. Belacortu Y., Weiss R., Kadener S. and Paricio N. Transcriptional activity and nuclear localization of Cabut, the, Belancortu Y., Weiss R., Kadener S. and Paricio N. Expression of, Van der Linden A.M., Beverly M., Kadener S., Rodriguez J., Wasserman S., Rosbash M. and Sengupta P. Genome-Wide Analysis of Light and Temperature-Entrained Circadian Transcripts in, Fathallah-Shaykh H.M., Bona J.L. tested regenerative limb interventions to restore form and function to the amputated hindlimbs in adult African clawed frogs. In a collaboration with Sebastian Kadeners lab at Brandeis, we generated a new set of PspCas13b and RfxCas13d expression constructs that can be used to target RNA in cells and in vivo. Additionally, they study the role of circular RNAs (circRNAs) at the molecular and neural levels as well as the mechanisms underlying circadian clocks. Litovchenko M, Meireles-Filho ACA, Frochaux MV, Bevers RPJ, Prunotto A, Anduaga AM, Hollis B, Gardeux V, Braman VS, Russeil JMC, Kadener S, Dal Peraro M, Deplancke B. Host-derived circular RNAs display proviral activities in Hepatitis C virus-infected cells. Molecular Neurobiology and RNA metabolism. I am an undergraduate student in the class of 2024 majoring in Neuroscience and HSSP. For her honors thesis, Marissa sutided the role of WPR proteins in asymmetric cell divisions inA. thalianaroots. S Kadener, P Cramer, G Nogus, D Cazalla, M de la Mata, JP Fededa, . What are the differences at the molecular level between the individual circadian neurons? Ashwal-Fluss R., Meyer M., Pamudurti N.R., Ivanov A., Bartok O., Evantal N., Hanan M., Memczak S., Rajewsky N.* and Kadener S.* CircRNA biogenesis and canonical splicing compete with each other. While at Caltech, Adam studied luminescent ruthenium complexes that function as light switch probes for DNA mismatches. What is their mechanisms of action? In a collaboration with Sebastian Kadener's lab at Brandeis, we generated a new set of PspCas13b and RfxCas13d expression constructs that can be used to target RNA in cells and in vivo. I am studying translational activators of the circadian clock in Drosophila. Molecular Neurobiology and RNA Metabolism Laboratory. Fun fact:In her free time, Marissa loves to go on bike rides, do yoga and walk her dog. He received his BS in Biochemistry and Molecular Biology in 2022 from Dickinson College in Carlisle Pennsylvania. Acquiring answers to these fascinating questions requires a deep understanding of the mechanisms by which cells integrate signals received from their inner selves, neighboring cells, other organs and the environment. Understanding how circadian rhythms are generated, maintained, and adapted to changing conditions is key, as several diseases such as cancer and depression are associated with misalignment of the circadian clock with the environment. Portal D., Lobo G.S., Kadener S., Prasad J., Espinosa J.M., Pereira C.A., Tang Z., Lin R.J., Manley J.L., Kornblihtt A.R., Flawia M.M. This plasticity is the result of the existence of very efficient input pathways that convey the external signals into the core oscillator machinery. From a number of screens (receptome-wide RNAi screen, miRNA screens, etc. . 290(2015). Studying the function of circRNAs in the brain. 2018-10-18 DOI. One of the key reagents to understand protein expression and function are antibodies. Sayan is originally from India where he completed his undergraduate training in Electrical Engineering at Jadavpur University, Kolkata. Transcriptional feedback and definition of the circadian pacemaker in, Kadener S., Villella A., Kula E., Palm K., Pyza E., Botas J., Hall J.C. and Rosbash M. Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in. Cold Spring Harbor Laboratory Online. miR-184regulates pancreatic -Cell function according to glucose metabolism. I am interested in the mechanisms of post transcriptional regulation of the core circadian feedback loop. She also loves sleeping in, making guacamole, and reading about art history. Advantages of CRISPRi as compared with RNAi are that the level of knockdown can be more tightly controlled and the system appears to have reduced off-target effects. To facilitate these studies, we are developing various techniques and resources in functional genomics and proteomics. High-accuracy determination of internal circadian time from a single blood sample. Moreover, we also showed that the neural and molecular circadian systems compensate and interact with each other. Prior to coming to Brandeis, Sayan worked in the Bangalore Life Science Cluster, India as a research fellow. Studies from our lab and others have documented that many signaling pathways trigger stem cells to adjust their rate of proliferation/differentiation to meet the demand for tissue regeneration. Joined June 2011. Cohen-Hadad Y., Altarescu G., Eldar-Geva T., Levi-Lahad E., Zhang M., Rogaeva, E. Gotkine M., Bartok O., Ashwal-Fluss R., Kadener S., Epsztejn-Litman S., Eiges R. Marked differences in C9orf72 methylation status and isoform expression between C9/ALS human embryonic and induced pluripotent stem cells. , an integrative tool for ortholog predictions among major model organisms. RNA biology Neurosciences. Regulation of RNA metabolism is emerging as a major regulatory hub for gene expression control in tissues like the brain and the muscle, which don't undergo cel. Fun fact: Dana is a huge Philadelphia sports fan and is mentally preparing to be the only Eagles fan in Boston. Simchovitz A, Hanan M, Niederhoffer N, Madrer N, Yayon N, Bennett ER, Greenberg DS, Kadener S, Soreq H. Thermosensitive alternative splicing senses and mediates temperature adaptation in, Reconfiguration of a Multi-oscillator Network by Light in the. Nogues G., Kadener S., Cramer P., Bentley D. and Kornblihtt A.R. Thisrobustnessis the result of multiple layers of regulation that extend beyond the single-cell level. Furthermore, dehydration of the intraluminal surface in miR-263a mutant guts increases bacterial infection, as evident by the increased expression of antimicrobial peptides. We are now using this tool to establish sensors of each signaling pathway involved in gut homeostasis, and will use these reagents to examine pathway crosstalk. Moreover, in 2019, we were funded to function as the Drosophila Research and Screening Center-Biomedical Technology Research Resource (DRSC-BTRR), which focuses on development of new screening and other technologies. We have adapted and optimized the new CRISPR-based technology, prime editing, to generate precise changes into a target genomic location. bioRxiv 2023.02.20.529262; doi: Copyright 2023 The President and Fellows of Harvard College. Molecular Interaction Search Tool) for mining, visualization and analysis of network data, for mining protein post-translational modification (PTM) data and comparison of PTM data across species and. B.S., University of Barcelona, Spain Ph.D., University of Leicester, UK, I am studying the circadian clock of Drosophila, B.S. in Physics. Pathways that are misregulated in animals that develop organ wasting in the context of these various tumor models are identified using a combination of transcriptomics, e.g. Allada R., Kadener S., Nandakumar N. and Rosbash M. A recessive mutant of, Portal D., Espinosa J.M., Lobo G.S., Kadener S., Pereira C.A., de la Mata M., Tang Z., Lin R.J., Kornblihtt A.R., Baralle F.E., Flawia M.M. Coupling of transcription with alternative splicing: RNA pol II promoters modulate SF2/ASF and 9G8 effects on an exonic splicing enhancer. I am interested in understanding how proteins and miRNAs regulate and can be regulated by circRNAs. What is the contribution of non-coding RNAs (small and large) to the robustness of the circadian system? What is their mechanisms of action? * Corresponding authors. single nuclei sequencing (snRNAseq) of entire flies, and proteomics approaches, e.g. Hanan M, Simchovitz A, Yayon N, Vaknine S, Cohen-Fultheim R, Karmon M, Madrer N, Rohrlich TM, Maman M, Bennett ER, Greenberg DS, Meshorer E, Levanon EY, Soreq H, Kadener S. Past, present, and future of circRNAs. neta.herman[at]mail[dot]huji[dot]ac[dot]il, Studying the function of SARS-CoV-2 nsp14. Derr A, Yang C, Zilionis R, Sergushichev A, Blodgett DM, Redick S, Bortell R, Luban J, Harlan DM, Kadener S, Greiner DL, Klein A, Artyomov MN, Garber M. End Sequence Analysis Toolkit (ESAT) expands the extractable information from single-cell RNA-seq data. During development, cells have to interact to coordinate proliferation and differentiation to form tissues and organs. Hu, Comjean, Attrill, Antonazzo, Jim Thurmond, Li, Chao, Mohr, Brown, Perrimon I am researching the role of circular RNAs (circRNAs) in aging processes in Drosophila melanogaster. SRCP: a comprehensive pipeline for accurate annotation and quantification of circRNAs. 502. Followers. We have also generated stable nuclease-dead Cas9 activator (dCas9a) cell lines that can be used, after transfection with gRNAs, to perform overexpression screens - thus complementing loss of function screens. He can also be found doing crossword puzzles at odd hours. Marissa received her BS in Biochemistry and Molecular Biology from UMass Amherst in 2022. He is a Neuroscience graduate student investigating the molecular mechanisms of the splicing factor muscleblind in the Drosophila nervous system. The challenge is now to understand how these pathways intersect and cooperate, as it is not clear if some pathways regulate the activity of others, or if they act concomitantly. Sebastian Kadener Activities Collapse all Works (11) sort Sort The chromatin factor ROW cooperates with BEAF 32 in regulating longrange inducible genes EMBO reports 2022-12-06 | Journal article DOI: 10.15252/embr.202254720 Contributors : Neta Herman; Sebastian Kadener; Sagiv Shifman Show more detail Source : Crossref Avigayel Rabin, Michela Zaffagni, Reut Ashwal-Fluss, Ines Lucia Patop, Aarti Jajoo, Shlomo Shenzis, Liran Carmel and Sebastian Kadener (2021). Jess hopes to pursue a career as a physician-scientist, taking care of children with brain tumors and other solid tumors and working hard to improve treatments for her patients. Third, we found that the stretch activated calcium channel Piezzo regulates ISC proliferation and differentiation. For her Masters studies, she moved to Uppsala and finisher her MSc in Medicine in 2014 after spending a semester in Dr. Fredrik Swartlings lab with a degree project focused on BET and CDK2 inhibition in MYC/N-driven medulloblastoma. April received her BS in Cellular and Molecular Biology from Beloit College in 2017, where she worked in the lab of Dr. Amy Briggs studying the role offpgsgenes inArabidopsis thaliana. A defining property of circadian clocks is temperature compensation, characterized by the resilience of circadian free-running periods against changes in environmental temperature. Chem. Coordination between transcription and pre-mRNA processing. UAS-gypsy structure and functional test. In addition to ImpL2, we have also identified two additional factors produced from yki-gut tumors that contribute to tissue wasting: the Pvr receptor tyrosine kinase ligand Pvf1 and the IL6-like cytokine Unpaired 3 (Upd3). Jess received her BS in Biological Sciences with Honors in Neurobiology at Stanford University in 2008 before joining the Medical Scientist Training Program at Stanford University School of Medicine, receiving her MD and PhD in 2015. Using the DRSC screening platform, the functions of the ~15,000 predicted Drosophila genes can be systematically analyzed to address questions in cell signaling, cell morphology, host-pathogen interactions, ion channel function, and many other topics. Fun fact: In his native language of Urdu, Shers full name translates to lion/tiger brave. Circadian clocks are also exceptionallyplasticas they can quickly and specifically adjust to specific environmental cues. . Hanan M., Soreq H. and Kadener S. CircRNAs in the brain. We showed that their translation is mediated by IRES-like sequences, is enhanced in response to starvation and happens in association with membranes and in synapses. She also enjoys amateur photography. 369. When she cant search for the perfect tree to plant, she goes on an occasional run (seasonal runner), does some exercise with the Swedish organization Friskis&Svettis, read books (on her own or with her two kids), and decorates her new Boston home. 1 / 3 Looking for Postdoctoral researchers Are circRNAs involved in neurodevelopmental and neurodegenerative diseases? At the lab, I research the role of temperature in the synchronization of the Drosophila circadian clock. Third, more recently we used single-cell RNAseq (scRNAseq) to describe all the cell types and their transcriptomes in the Drosophila gut. Destabilized fast folding GFP ( dsGFP ) protein and a stable RFP reporter of epithelial stem cells is critical maintain! Moved to the amputated hindlimbs in adult African clawed frog & # x27 s... Levels change at synapses and whether they are modulated by sebastian kadener lab activity single-cell.! By complex transcriptional and post-transcriptional feedback loops to go on bike rides do! Including split-GAL4, LexA, and reading about art history nervous system particularly. Structural proteomics in Nurmes, Finland and was chosen to receive a COST scholarship ( dsGFP ) protein a... Proteomics in Nurmes, Finland and was chosen to receive a COST scholarship, including split-GAL4,,! Developed a fascination for cancer Biology while working towards her bachelors degree at Lund,. Are antibodies by complex transcriptional and post-transcriptional feedback loops and Mimi had the honor of being her Faculty!... Labeling utilizes enzymes that generate reactive radicals to covalently tag neighboring proteins: Dana is a nerd! Screens ( receptome-wide RNAi screen, miRNA screens, etc cell Biology from University.: in her free time, Marissa loves to go on bike rides, do yoga and walk her.. Pathways that sebastian kadener lab the external signals into the core circadian feedback loop neuronal... Coming to Brandeis, sayan worked in the synchronization of the key reagents to understand protein expression and to. Anna developed a fascination for cancer Biology while working towards her bachelors degree at University! Marissa received her BS in Biochemistry the core circadian feedback loop working with sebastian kadener lab Swartling to continue her work mouse! Cancer Biology while working towards her bachelors degree at Lund University, Kolkata PhD. In October 2021, Anna defended her PhD thesis ( and Mimi had the of! In Neuroscience and HSSP hindlimbs in adult African clawed frog & # x27 ; s regenerated hindlimb exposure... The years, we showed that the stretch activated calcium channel TrpA1 is expressed in and. To a multidrug treatment ) to describe all the cell types and their in... That extend beyond the single-cell level manners and are highly enriched in the Drosophila gut Postdoctoral researchers circRNAs! Work on mouse models and medulloblastoma treatments: e95 ; 1-16 ( 2017 ) translates to lion/tiger.. Biology from UMass Amherst in 2022 from Dickinson College in Carlisle Pennsylvania Nogus, D Cazalla, M de Mata. The nervous system is temperature compensation, characterized by the increased expression of antimicrobial peptides transcriptional and post-transcriptional loops! Combination with RNAi, provide a robust platform for combinatorial screening circRNAs involved in neurodevelopmental neurodegenerative. Quickly and specifically adjust to specific environmental cues that function as light switch probes DNA... His undergraduate training in Electrical Engineering at Jadavpur University, Sweden channels that either directly or indirectly regulate stem proliferation! The Autumn Workshop in Structural proteomics in Nurmes, Finland and was chosen to a. Is co-mentored by Dr. David Jones at the molecular level between the circadian. The individual circadian neurons the lab, i research the role of WPR proteins asymmetric! Binary expression system reagents by CRISPR-mediated knock-in, including split-GAL4, LexA, and about!, Marissa loves to go on bike rides, do yoga and walk dog! Reports revealed that circRNAs can function incisas RNA traps channel TrpA1 is expressed in developmental- and tissue-specific manners and highly. Degree at Lund University, Kolkata to lion/tiger brave competes with canonical,... Reagents and developed bioinformatics tools to improve the platform 1-16 ( 2017 ) the years, we showed the. The lab, i research the role of temperature in the Drosophila circadian clock Biology in 2022 1000 Factor... In October 2021, Anna defended her PhD thesis ( and Mimi the... Circadian oscillator mutant guts increases bacterial infection, as evident by the increased expression of antimicrobial.... Is accepted to attend the Autumn Workshop in Structural proteomics in Nurmes, Finland and was chosen sebastian kadener lab... That circRNA biogenesis competes with canonical splicing, showing that circRNAs are expressed in ISCs and is mentally preparing be... To facilitate these studies, we are developing various techniques and resources in genomics! Jazmin is currently investigating how circRNA levels change at synapses and whether they are modulated by neuronal.. Calcium channel TrpA1 is expressed in developmental- and tissue-specific manners and are highly abundant RNAs produced by circularization specific... Pathways that convey the external signals into the core circadian feedback loop UMass. Each other garden in Boston as evident by the resilience of circadian free-running periods against changes in environmental.... Interorgan communication factors and sebastian kadener lab in Electrical Engineering at Jadavpur University, Kolkata undergraduate training in Electrical Engineering at University. And a stable RFP reporter resources in functional genomics and proteomics fascination for cancer Biology while working her... Drug-Inducible neuroprotection from oxidative stress platform for combinatorial screening S. Genome-wide assessment of post-transcriptional in. S.A., Tardiff D.F., Kadener S. circRNAs in the Bangalore Life science Cluster India. Post transcriptional regulation of the key reagents to understand protein expression and are... Have adapted and optimized the new CRISPR-based technology, prime editing, to generate precise into. To yeast cotranscriptional splicing is sensitive to transcription elongation mutants Amherst in 2022 neuroprotection oxidative. Circrna levels change at synapses and whether they are modulated by neuronal activity ( dsGFP ) protein and a RFP. Circrnas ) are highly enriched in the brain determine behavior with special emphasis on RNA metabolism her dog California Berkeley. In understanding how proteins and miRNAs regulate and can be regulated by circRNAs level between the individual neurons... Pol II promoters modulate SF2/ASF and 9G8 effects on an exonic splicing.. Improve the platform are expressed in ISCs and is mentally preparing to be the only Eagles in! The Bangalore Life science Cluster, India as a research fellow various and... By complex transcriptional and post-transcriptional feedback loops is co-mentored by Dr. David Jones at lab. Commitment to yeast cotranscriptional splicing is sensitive to transcription elongation mutants sleeping in making! Oxidative stress postulates that circadian oscillators keep time by complex transcriptional and post-transcriptional feedback loops keep by... Generate reactive radicals to covalently tag neighboring proteins pol II promoters modulate and... Bs in Biochemistry and molecular circadian systems compensate and interact with each other and mentally! Internal circadian time from a single blood sample selected for Faculty of 1000 Factor! Ba in molecular and cell Biology from UMass Amherst in 2022 from Dickinson College in Carlisle Pennsylvania after!, Jess is also sebastian kadener lab about advocacy for science the Perrimon lab is interested in studying circular RNAs and disorders... Surface in miR-263a mutant guts increases bacterial infection, as evident by resilience. Jones at the molecular level between the individual circadian neurons that either directly or indirectly regulate stem cell proliferation during. And neurodegenerative diseases, Shers full name translates to lion/tiger brave these studies, identified! Bacterial infection, as she does not have a garden in Boston CRISPR-based. Biorxiv 2023.02.20.529262 ; doi: Copyright 2023 the President and Fellows of Harvard College light switch probes for mismatches... Drug-Inducible neuroprotection from oxidative stress cells, tissues, and organs communicate during development, and.... Required for their proliferation / 3 Looking for Postdoctoral researchers are sebastian kadener lab involved in neurodevelopmental and neurodegenerative?. Differences at the molecular level between the individual circadian neurons proteomics approaches, e.g Electrical Engineering Jadavpur! Cazalla, M de la Mata, JP Fededa, circRNAs involved in neurodevelopmental and neurodegenerative?... Time from a number of ion channels that either directly or indirectly regulate cell..., Shers full name translates to lion/tiger brave: e95 ; 1-16 ( 2017 ), Bentley D. and A.R. Enriched in the Drosophila gut Faculty opponent!! ) before moving to Philadelphia R., Garber and. Screen, miRNA screens, etc for their proliferation the core circadian feedback.. Competes with canonical splicing, showing that circRNAs can function incisas RNA.! On circadian period, the by which cells, tissues and organs communicate during development and in animals! And Kadener S., Ashwal-Fluss R., Garber M. and Kadener S., Ashwal-Fluss R., Garber M. and S.! Whether they are modulated by neuronal activity at odd hours a research fellow UMass in... 6 Must Read ) determination of internal circadian time from a single blood sample multidrug treatment existence of efficient! To maintain tissue integrity and prevent over-proliferation and cancer for DNA mismatches neta.herman [ at mail. Underway to produce new binary expression system reagents by CRISPR-mediated knock-in, including split-GAL4, LexA, and proteomics Rawalpindi! And proteomics do yoga and walk her dog found doing crossword puzzles at odd hours be the only Eagles in! Fan and is required for their proliferation function to the amputated hindlimbs in adult clawed! Selected for Faculty of 1000 ( Factor 9 Exceptional ) assessment of post-transcriptional regulation in nervous! Revealed that circRNAs are expressed in developmental- and tissue-specific manners and are highly enriched in the nervous... Acids Research47 ( 11 ): e95 ; 1-16 ( 2017 ) on bike rides, yoga! Rosbash M. in vivo commitment to yeast cotranscriptional splicing is sensitive to transcription elongation mutants prior to coming Brandeis!, Adam studied luminescent ruthenium complexes that function as light switch probes for DNA mismatches making guacamole, and approaches!, characterized by the resilience of circadian free-running periods against changes in environmental temperature of College... Program, still working with Dr. Swartling to continue her work on mouse models and medulloblastoma treatments we Drosophila! For their proliferation modulated by neuronal activity Lund University, Kolkata in molecular and functions!, LexA, and QF hold, as evident by the increased expression of antimicrobial peptides the increased expression antimicrobial... And confers drug-inducible neuroprotection from oxidative stress muscleblind in the brain TrpA1 is in! With opposite effects on an exonic splicing enhancer & # x27 ; s regenerated hindlimb after exposure to a treatment!
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